Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.64 |
| ▸ | ITGAV | P06756 | 13/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.64 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.64 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500489 | 1.00 | ITGB3 (0.64) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500969 | 0.83 | ITGB3 (0.74) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500973 | 0.83 | ITGB3 (0.74) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7497894 | 0.78 | ITGB3 (0.62) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7497901 | 0.78 | ITGB3 (0.62) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7495439 | 0.78 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7495445 | 0.78 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500047 | 0.77 | ITGB3 (0.66) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7498381 | 0.77 | ITGB3 (0.71) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500038 | 0.77 | ITGB3 (0.66) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | claimed |
| EP-0894084-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-02-03 | — | — | EP | claimed |
| WO-1997036860-A1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | disclosed |