SCHEMBL7500513

SCHEMBL7500513

COc1ccnc(C(=O)c2[nH]c3cc(Cl)ccc3c2NC(C)=O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.47
HSD17B10 Q99714 3/20 0.44
ALDH1A1 P00352 3/20 0.44
KDM4E B2RXH2 3/20 0.44
HPGD P15428 2/20 0.44
PTGS1 P23219 1/20 0.43
USP2 O75604 1/20 0.42
MAPK1 P28482 1/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
ALOX15 P16050 1/20 0.42
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
MCL1 Q07820 2/20 0.41
MAPT P10636 3/20 0.40
BCHE P06276 1/20 0.40
ACHE P22303 1/20 0.40
DYRK1A Q13627 1/20 0.40
TUBB4A P04350 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7507514 0.89 PTGS2 (0.44) PTGS2HSD17B10ALDH1A1KDM4EHPGD
SCHEMBL6951215 0.88 PTGS2 (0.44) PTGS2HSD17B10ALDH1A1KDM4EPTGS1
SCHEMBL7503000 0.87 PTGS2 (0.45) PTGS2HSD17B10ALDH1A1KDM4EHPGD
SCHEMBL7503474 0.86 PTGS2 (0.48) PTGS2KDM4EPTGS1MEN1KMT2A
SCHEMBL7508427 0.84 PTGS2 (0.43) PTGS2KDM4EPTGS1MEN1KMT2A
SCHEMBL8135808 0.83 PTGS2 (0.48) PTGS2PTGS1ALOX15MCL1MAPT
SCHEMBL7505343 0.83 KDM4E (0.52) PTGS2HSD17B10ALDH1A1KDM4EHPGD
SCHEMBL7507760 0.83 KDM4E (0.46) PTGS2ALDH1A1KDM4EHPGDMEN1
SCHEMBL7501686 0.82 MEN1 (0.44) PTGS2KDM4EMEN1KMT2AMAPT
SCHEMBL7512477 0.82 KDM4E (0.48) PTGS2HSD17B10ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001934-B1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER (US) 2002-11-27 EP claimed
US-6300363-B1 USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS PFIZER INC. 2001-10-09 US claimed
EP-1001934-A1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 2000-05-24 EP claimed
WO-1999005104-A1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 1999-02-04 WO claimed
EP-1001934-B1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER (US) 2002-11-27 EP disclosed
US-6300363-B1 USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS PFIZER INC. 2001-10-09 US disclosed
EP-1001934-A1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 2000-05-24 EP disclosed
WO-1999005104-A1 INDOLE COMPOUNDS AS COX-2 INHIBITORS PFIZER PHARMACEUTICALS INC. (JP) 1999-02-04 WO disclosed