Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 8/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675290 | 0.88 | LMNA (0.51) | LMNATP53MAPTL3MBTL1KDM4E | |
| SCHEMBL7507913 | 0.84 | LMNA (0.55) | LMNATP53MAPTL3MBTL1MEN1 | |
| SCHEMBL7765037 | 0.81 | LMNA (0.58) | LMNATP53MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL7765030 | 0.81 | LMNA (0.58) | LMNATP53MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4674725 | 0.81 | LMNA (0.61) | LMNATP53MAPTL3MBTL1KDM4E | |
| SCHEMBL4673603 | 0.75 | LMNA (0.51) | LMNATP53MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4672936 | 0.74 | LMNA (0.51) | LMNATP53MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL7508099 | 0.74 | LMNA (0.51) | LMNATP53MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4674018 | 0.73 | LMNA (0.60) | LMNATP53MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL4674019 | 0.73 | LMNA (0.60) | LMNATP53MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |