Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352105 | 0.81 | CYP3A4 (0.33) | MAP3K14CYP3A4CYP2C9ALDH1A1MAPT | |
| SCHEMBL27824101 | 0.79 | ALDH1A1 (0.31) | CYP3A4CYP2C9ALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL7498143 | 0.79 | CYP3A4 (0.34) | CYP3A4CYP2C9MEN1KMT2AMAPT | |
| SCHEMBL4575125 | 0.79 | APP (0.34) | CYP3A4CYP2C9ALDH1A1MAPTCYP2C19 | |
| SCHEMBL6634450 | 0.76 | ALDH1A1 (0.35) | CYP3A4CYP2C9ALDH1A1MEN1KMT2A | |
| SCHEMBL10396982 | 0.76 | PIK3CD (0.33) | PIK3CDPIK3R1MAP3K14 | |
| SCHEMBL4163641 | 0.73 | CYP3A4 (0.49) | CYP3A4CYP2C9ALDH1A1KMT2AMAPT | |
| SCHEMBL6849960 | 0.73 | CYP11B1 (0.32) | CYP3A4CYP2C9ALDH1A1MAPTCYP2C19 | |
| Bromide SCHEMBL7554050 | 0.72 | CYP3A4 (0.48) | CYP3A4CYP2C9ALDH1A1KMT2AMAPT | |
| SCHEMBL4888078 | 0.69 | CYP3A4 (0.60) | CYP3A4CYP2C9CYP2C19CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971920-B1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | EP | disclosed |
| US-6265415-B1 | ANTIULCER AGENT | ASTRAZENECA AB (SE) | 2001-07-24 | — | — | US | disclosed |
| EP-0971920-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | Astra Aktiebolag (SE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998037080-A1 | COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION | ASTRA AKTIEBOLAG (SE) | 1998-08-27 | — | — | WO | disclosed |