Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | CLK2 | P49760 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.62 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265286 | 0.81 | CLEC4M (0.50) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL12764944 | 0.78 | CLEC4M (0.49) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL12764985 | 0.77 | CLEC4M (0.53) | MAPK1CLEC4MKDM4EHPGDKMT2A | |
| SCHEMBL6352557 | 0.77 | KDM4E (0.60) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL2993573 | 0.77 | MAPK1 (1.00) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL31686108 | 0.73 | TSHR (0.53) | PLK4DAPK3DYRK3JAK2PRKD3 | |
| SCHEMBL12764935 | 0.73 | PARP1 (0.61) | CLEC4MKDM4EHPGDKMT2AMEN1 | |
| SCHEMBL28370434 | 0.72 | KDM4E (0.60) | KDM4EHPGDKMT2AMEN1CYP1A2 | |
| SCHEMBL11737708 | 0.72 | CLEC4M (0.58) | CLEC4MKDM4EKMT2AMEN1CYP1A2 | |
| SCHEMBL6353901 | 0.72 | HTT (0.64) | GSK3BCDK5DYRK1AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652892-B1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1997-08-20 | — | — | EP | disclosed |
| EP-0652892-A1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY. | ZENECA LTD (GB) | 1995-05-17 | — | — | EP | disclosed |
| US-5405852-A | Amide derivatives | ZENECA LIMITED (GB) | 1995-04-11 | — | — | US | disclosed |
| WO-1993024519-A1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |