Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764944 | 0.86 | CLEC4M (0.49) | CLEC4MALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL12764935 | 0.85 | PARP1 (0.61) | CLEC4MALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL12764968 | 0.85 | GFER (0.49) | ALDH1A1KDM4EMAPTGFERALOX15 | |
| SCHEMBL12764963 | 0.83 | GFER (0.47) | ALDH1A1KDM4EMAPTGFERALOX15 | |
| SCHEMBL12764941 | 0.79 | MTHFD2 (0.54) | CLEC4MALDH1A1L3MBTL1LMNATSHR | |
| SCHEMBL7500905 | 0.77 | PLK4 (0.62) | CLEC4MALDH1A1KDM4EMAPTALOX15 | |
| SCHEMBL11737708 | 0.77 | CLEC4M (0.58) | CLEC4MALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL30804630 | 0.73 | KDM4E (0.62) | CLEC4MALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL6045360 | 0.73 | KDM4E (0.62) | CLEC4MALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL12765014 | 0.72 | PARP1 (0.45) | KDM4EMAPTGFERALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071136-A1 | NOVEL TRICYCLIC PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071136-A1 | NOVEL TRICYCLIC PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC (US) | 2011-03-24 | — | — | US | disclosed |
| WO-2011035019-A1 | NOVEL TRICYCLIC PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071136-A1 | NOVEL TRICYCLIC PROTEIN KINASE MODULATORS | PACSIN2, CSNK2A3, CKS2 | CLEC4M 2642/4885ALDH1A1 4683/4885KDM4E 2127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.