Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.59 |
| ▸ | CDK4 | P11802 | 3/20 | 0.58 |
| ▸ | CCND1 | P24385 | 3/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.58 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496997 | 0.92 | GSK3B (0.64) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7529336 | 0.86 | CCNE2 (0.77) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7495252 | 0.86 | PRKCA (0.61) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7054131 | 0.86 | CCNE2 (0.76) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7501138 | 0.85 | GSK3B (0.61) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7497412 | 0.85 | GSK3B (0.62) | GSK3BCDK4CCND1CDK2CCNE2 | |
| Hydrochloric Acid SCHEMBL7500381 | 0.84 | GSK3B (0.61) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7504842 | 0.84 | PRKCA (0.56) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL7498988 | 0.82 | GSK3B (0.61) | GSK3BCDK4CCND1CDK2CCNE2 | |
| SCHEMBL8439689 | 0.81 | GSK3B (0.54) | GSK3BCDK4CCND1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | claimed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | claimed |
| EP-0915870-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | claimed |
| WO-1998004551-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | claimed |
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |