Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17163357 | 0.90 | CYP3A4 (0.53) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 | |
| SCHEMBL950871 | 0.90 | CYP3A4 (0.53) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 | |
| SCHEMBL13201397 | 0.90 | CYP3A4 (0.53) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL1036101 | 0.89 | CYP3A4 (0.51) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 | |
| SCHEMBL22254433 | 0.86 | ALDH1A1 (0.47) | CYP2D6ALDH1A1SIGMAR1TSHRPOLB | |
| SCHEMBL2284694 | 0.83 | CYP2D6 (0.59) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 | |
| SCHEMBL867675 | 0.83 | GAA (0.62) | CYP2D6SIGMAR1TSHRCYP3A4GAA | |
| SCHEMBL25542043 | 0.82 | KCNH2 (0.50) | CYP2D6ALDH1A1SIGMAR1TSHRPOLB | |
| SCHEMBL24315810 | 0.81 | CYP2D6 (0.56) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 | |
| SCHEMBL6378751 | 0.81 | CYP2D6 (0.57) | CYP2D6ALDH1A1SIGMAR1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723545-B1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LAB (US) | 2002-05-08 | — | — | EP | disclosed |
| CN-1053188-C | Quinolizinone type compounds | ABBOTT LAB (US) | 2000-06-07 | — | — | CN | disclosed |
| EP-0871628-A1 | QUINOLIZINONE TYPE COMPOUNDS | Abbott Laboratories (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5726182-A | TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1998-03-10 | — | — | US | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |
| CN-1137273-A | Quinolizinone type compounds | ABBOTT LAB (US) | 1996-12-04 | — | — | CN | disclosed |
| US-5580872-A | ADMINISTERING IN THE TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1996-12-03 | — | — | US | disclosed |
| EP-0723545-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010519-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1995-04-20 | — | — | WO | disclosed |