Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NCK1 | P16333 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15241824 | 0.78 | HTR2A (0.51) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL171810 | 0.76 | CYP2A6 (0.55) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL16887870 | 0.74 | HTR2C (0.50) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL20614498 | 0.74 | HTR2A (0.47) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL27987689 | 0.74 | HTR2A (0.47) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL28022326 | 0.74 | HTR2A (0.47) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL28027731 | 0.74 | HTR2A (0.47) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL20807250 | 0.71 | HTR2C (0.61) | HTR2AHTR2CHTR7MAPTRXFP1 | |
| SCHEMBL13183604 | 0.71 | HTR2A (0.45) | HTR2AHTR2CCYP1A2CYP2A6HTR7 | |
| SCHEMBL10193356 | 0.71 | HTR2C (0.62) | HTR2AHTR2CCYP1A2CYP2A6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |
| EP-0915870-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004551-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |