Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.48 |
| ▸ | RXRA | P19793 | 4/20 | 0.48 |
| ▸ | RXRB | P28702 | 4/20 | 0.48 |
| ▸ | RXRG | P48443 | 3/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | C5 | P01031 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501412 | 0.93 | PTGS2 (0.60) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL7505591 | 0.93 | NR4A2 (0.55) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL7503374 | 0.93 | NR4A2 (0.55) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL9095581 | 0.89 | PTGS2 (0.62) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL7505153 | 0.89 | PTGS2 (0.62) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL7501237 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL7505500 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL7498736 | 0.86 | CA1 (0.60) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL7499819 | 0.86 | CA1 (0.60) | PTGS2PTGS1CA1CA2NR4A2 | |
| SCHEMBL8558542 | 0.85 | PTGS2 (0.43) | PTGS2PTGS1NR4A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | claimed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | disclosed |