Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7501028 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL7505168 | 0.88 | SCN9A (0.44) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL7505172 | 0.88 | SCN9A (0.44) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL7501113 | 0.85 | ALDH1A1 (0.45) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL27398774 | 0.85 | ALDH1A1 (0.45) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL7501111 | 0.85 | ALDH1A1 (0.45) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL9142205 | 0.85 | ALDH1A1 (0.45) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL4024927 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL4024929 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 | |
| SCHEMBL9052088 | 0.78 | KMT2A (0.40) | SMN1; SMN2SCN9AALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723545-B1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LAB (US) | 2002-05-08 | — | — | EP | disclosed |
| US-5726182-A | TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1998-03-10 | — | — | US | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |
| US-5580872-A | ADMINISTERING IN THE TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1996-12-03 | — | — | US | disclosed |
| WO-1995010519-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1995-04-20 | — | — | WO | disclosed |