Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498294 | 0.88 | GSK3B (0.52) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7508084 | 0.79 | GSK3B (0.59) | GSK3BPRKCA | |
| SCHEMBL7506750 | 0.78 | CCNE2 (0.45) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7502427 | 0.77 | GSK3B (0.75) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7507263 | 0.76 | GSK3B (0.65) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7499657 | 0.74 | GSK3B (0.70) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL8155150 | 0.74 | PRKCA (0.80) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL30834696 | 0.72 | CCNE2 (0.58) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7529336 | 0.71 | CCNE2 (0.77) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL8440476 | 0.69 | CCNE2 (0.72) | GSK3BCCNE2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |