Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.56 |
| ▸ | CCND1 | P24385 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496693 | 0.94 | GSK3B (0.57) | GSK3BCDK2GSK3ACDK4CCND1 | |
| SCHEMBL7508119 | 0.92 | CCNE2 (0.56) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL668748 | 0.90 | CCNE2 (0.57) | CDK2CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7507328 | 0.88 | PRKCA (0.52) | GSK3BCDK2CDK4CCND1PRKCA | |
| Enmd-981693 SCHEMBL29350364 | 0.86 | CCNE2 (0.69) | GSK3BCDK2CDK4CCND1CCNE2 | |
| Enmd-981693 SCHEMBL608128 | 0.86 | CCNE2 (0.69) | GSK3BCDK2CDK4CCND1CCNE2 | |
| SCHEMBL4420386 | 0.86 | GSK3B (0.68) | GSK3BCDK2GSK3ACDK4CCND1 | |
| SCHEMBL7499922 | 0.84 | GSK3B (0.55) | GSK3BCDK2CDK4CCND1CCNE2 | |
| SCHEMBL7497956 | 0.84 | GSK3B (0.57) | GSK3BCDK2CDK4CCND1PRKCA | |
| SCHEMBL7506705 | 0.84 | CDK2 (0.51) | GSK3BCDK2CDK4CCND1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |
| EP-0915870-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004551-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |