Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 14/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509098 | 0.89 | MKNK2 (0.46) | MKNK2MKNK1HRH1HRH4LCK | |
| SCHEMBL7501017 | 0.88 | MKNK2 (0.54) | MKNK2MKNK1HRH1HRH4LCK | |
| SCHEMBL7500919 | 0.86 | LCK (0.54) | MKNK2MKNK1HRH1HRH4LCK | |
| SCHEMBL7509636 | 0.85 | MKNK1 (0.59) | MKNK2MKNK1HRH4LCK | |
| SCHEMBL7499230 | 0.84 | MKNK2 (0.59) | MKNK2MKNK1HRH1HRH4LCK | |
| SCHEMBL7569631 | 0.83 | LCK (0.55) | MKNK2MKNK1LCK | |
| SCHEMBL7019115 | 0.83 | LCK (0.55) | MKNK2MKNK1LCK | |
| SCHEMBL7505082 | 0.80 | MKNK1 (0.60) | MKNK2MKNK1HRH4LCK | |
| SCHEMBL7511562 | 0.80 | MKNK2 (0.49) | MKNK2MKNK1HRH1HRH4LCK | |
| SCHEMBL7504892 | 0.79 | MKNK2 (0.46) | MKNK2MKNK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |