Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507890 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7504311 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7508748 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7505284 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7506242 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7507638 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7508929 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7506263 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7508244 | 1.00 | ALOX15 (0.49) | ALOX15GSK3BALDH1A1HPGDHSD17B10 | |
| SCHEMBL7514736 | 0.99 | ALOX15 (0.48) | ALOX15GSK3BALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |