Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL593957 | 0.88 | AAK1 (0.47) | AAK1CYP2D6MAPK14MAPK12TNF | |
| SCHEMBL592972 | 0.88 | AAK1 (0.47) | AAK1CYP2D6MAPK14MAPK12TNF | |
| SCHEMBL4689617 | 0.83 | AAK1 (0.44) | AAK1CYP2D6LMNAPOLBCDC25B | |
| SCHEMBL6279532 | 0.82 | BRD4 (0.48) | AAK1CYP2D6 | |
| SCHEMBL593474 | 0.82 | AAK1 (0.47) | AAK1CYP2D6CDC25BMAPTSMN1; SMN2 | |
| SCHEMBL4252948 | 0.81 | MAPK14 (0.52) | MAPK14MAPK12TNFHCKMAPK13 | |
| SCHEMBL18593710 | 0.80 | AAK1 (0.43) | AAK1CYP2D6MAPK14LMNAPOLB | |
| SCHEMBL4421726 | 0.80 | CASP3 (0.47) | AAK1CYP2D6LMNACDC25BMAPT | |
| SCHEMBL6636004 | 0.79 | AAK1 (0.42) | AAK1CYP2D6LMNAPOLBCDC25B | |
| SCHEMBL5257397 | 0.79 | MAPK14 (0.65) | MAPK14MAPK12TNFHCKMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1232150-A1 | UREA DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001036403-A1 | UREA DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-05-25 | — | — | WO | disclosed |