Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CCND1 | P24385 | 4/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6073874 | 0.90 | ALK (0.64) | SYKALKCDK4CCND1CCNE1 | |
| SCHEMBL6074010 | 0.85 | CDK2 (0.59) | SYKALKCDK4CCND1CCNE1 | |
| SCHEMBL6073852 | 0.82 | CDK4 (0.55) | SYKCDK4CCND1CCNE1CDK2 | |
| SCHEMBL7066974 | 0.78 | ALK (0.45) | SYKALKCDK4CCND1CCNE1 | |
| SCHEMBL7500309 | 0.74 | CDK2 (0.51) | SYKCDK4CCND1CCNE1CDK2 | |
| SCHEMBL7064739 | 0.74 | SYK (0.60) | SYKCDK4CCND1CCNE1CDK2 | |
| SCHEMBL12478815 | 0.73 | ALK (0.55) | SYKALKCDK4CCND1 | |
| SCHEMBL6073372 | 0.73 | JAK3 (0.46) | SYKCDK4CCND1CDK2 | |
| SCHEMBL6073369 | 0.73 | JAK3 (0.46) | SYKCDK4CCND1CDK2 | |
| SCHEMBL3837154 | 0.72 | CDK4 (0.56) | CDK4CCND1CCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254137-A1 | PYRIDO 2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055147-A1 | PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |