Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497697 | 0.89 | HTR1A (0.65) | HTR1ASLC6A4 | |
| SCHEMBL7494997 | 0.85 | HTR1A (0.74) | HTR1ASLC6A4 | |
| SCHEMBL7501333 | 0.81 | CDK2 (0.45) | HTR1ASLC6A4NPC1RAB9ACDK2 | |
| SCHEMBL7334310 | 0.80 | KDM4E (0.61) | HTR1ANPC1RAB9A | |
| SCHEMBL7843688 | 0.79 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7835876 | 0.79 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7846504 | 0.78 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL7833926 | 0.77 | HTR1A (1.00) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9272887 | 0.76 | HTR1A (0.81) | HTR1ASLC6A4 | |
| SCHEMBL7502129 | 0.76 | HTR1A (0.72) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068199-B1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1068199-A2 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6150533-A | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-1999051591-A2 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |