Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508178 | 0.90 | KDM4E (0.51) | KDM4EMEN1KMT2AGPR17MAPK1 | |
| SCHEMBL8543371 | 0.86 | GPR17 (0.52) | KDM4EMEN1KMT2AGPR17MAPK1 | |
| SCHEMBL7503003 | 0.85 | KDM4E (0.54) | KDM4EMEN1KMT2A | |
| SCHEMBL7506093 | 0.85 | KDM4E (0.47) | KDM4EMEN1KMT2AGPR17MAPK1 | |
| SCHEMBL7507314 | 0.85 | KDM4E (0.47) | KDM4EMEN1KMT2AGPR17MAPK1 | |
| SCHEMBL7506604 | 0.85 | ALOX15 (0.54) | KDM4EMEN1KMT2A | |
| SCHEMBL7505821 | 0.84 | KDM4E (0.50) | KDM4EMEN1KMT2AGPR17MAPK1 | |
| SCHEMBL7512559 | 0.82 | ALOX15 (0.57) | KDM4EMEN1KMT2A | |
| SCHEMBL4342284 | 0.82 | MAPT (0.56) | KDM4EMEN1KMT2AGPR17 | |
| SCHEMBL7505416 | 0.82 | KDM4E (0.50) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |