Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505878 | 0.85 | KDM4E (0.52) | KDM4EMCL1ALDH1A1HPGDMEN1 | |
| SCHEMBL7508887 | 0.85 | MCL1 (0.42) | KDM4EMCL1ALOX15ALDH1A1HPGD | |
| SCHEMBL7501923 | 0.85 | KDM4E (0.48) | KDM4EMCL1ALOX15TSHRALDH1A1 | |
| SCHEMBL7515430 | 0.82 | KDM4E (0.46) | KDM4EMCL1ALOX15TSHRALDH1A1 | |
| SCHEMBL7511408 | 0.82 | KDM4E (0.48) | KDM4EMCL1ALOX15ALDH1A1HPGD | |
| SCHEMBL7509500 | 0.81 | KDM4E (0.43) | KDM4EMCL1ALOX15IDH1TSHR | |
| SCHEMBL7505936 | 0.81 | KDM4E (0.44) | KDM4EMCL1ALOX15IDH1ALDH1A1 | |
| SCHEMBL7512389 | 0.79 | MAPT (0.47) | KDM4EMCL1ALDH1A1HPGDKMT2A | |
| SCHEMBL7511741 | 0.78 | KDM4E (0.43) | KDM4EALOX15ALDH1A1HPGDMEN1 | |
| SCHEMBL7514911 | 0.77 | KDM4E (0.47) | KDM4EMCL1ALOX15IDH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |