Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503922 | 0.86 | KDM4E (0.43) | KDM4EMCL1BCL2ALOX15TP53 | |
| SCHEMBL7505936 | 0.83 | KDM4E (0.44) | KDM4EMCL1IDH1ALOX15ALDH1A1 | |
| SCHEMBL7505878 | 0.82 | KDM4E (0.52) | KDM4EMCL1HPGDALDH1A1 | |
| SCHEMBL7501923 | 0.81 | KDM4E (0.48) | KDM4EMCL1ALOX15HPGDALDH1A1 | |
| SCHEMBL7511408 | 0.80 | KDM4E (0.48) | KDM4EMCL1ALOX15TP53HPGD | |
| SCHEMBL7515430 | 0.80 | KDM4E (0.46) | KDM4EMCL1BCL2ALOX15TP53 | |
| SCHEMBL7503000 | 0.79 | PTGS2 (0.45) | KDM4EMCL1IDH1ALOX15HPGD | |
| SCHEMBL7506486 | 0.78 | KDM4E (0.43) | KDM4EALOX15TP53 | |
| SCHEMBL7499985 | 0.77 | MAP2 (0.42) | MCL1BCL2ALOX15TP53SMN1; SMN2 | |
| SCHEMBL6168423 | 0.77 | PTGS2 (0.46) | MCL1BCL2TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |