Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.97 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.97 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.97 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444846 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7440108 | 0.88 | PDE4B (1.00) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL8885266 | 0.88 | PDE4B (0.81) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL1028427 | 0.88 | PDE4B (0.80) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL30009845 | 0.88 | PDE4B (0.80) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL7451207 | 0.87 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7406024 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL8461881 | 0.87 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| SCHEMBL9005494 | 0.86 | PDE4D (0.78) | PDE4APDE4BPDE4DPDE4CMAPK14 | |
| Hydrochloric Acid SCHEMBL6586041 | 0.86 | PDE4B (0.78) | PDE4APDE4BPDE4DPDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5691376-A | ANTIHISTAMINE, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-25 | — | — | US | disclosed |
| US-5650444-A | BRONCHODILATOR AGENTS, ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-07-22 | — | — | US | disclosed |
| EP-0745063-A1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995022520-A1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-08-24 | — | — | WO | disclosed |