Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 7/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506081 | 1.00 | SCN5A (0.38) | SCN5APIM3PIM1PIM2KCNH2 | |
| SCHEMBL15256899 | 0.93 | PIM1 (0.36) | PIM3PIM1PIM2CTSKKDM4D | |
| SCHEMBL10208012 | 0.93 | PIM1 (0.36) | PIM3PIM1PIM2CTSKKDM4D | |
| SCHEMBL7509631 | 0.91 | PIM1 (0.35) | PIM3PIM1PIM2CTSKKDM4D | |
| SCHEMBL8561869 | 0.88 | DYRK3 (0.44) | SCN5APIM3KCNH2DYRK3SRPK1 | |
| SCHEMBL6795089 | 0.88 | KCNH2 (0.36) | SCN5AKCNH2 | |
| SCHEMBL6795091 | 0.88 | KCNH2 (0.36) | SCN5AKCNH2 | |
| SCHEMBL6795087 | 0.88 | KCNH2 (0.36) | SCN5AKCNH2 | |
| SCHEMBL8571984 | 0.87 | SCN5A (0.39) | SCN5AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL6177905 | 0.87 | EIF2AK4 (0.35) | SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723545-B1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LAB (US) | 2002-05-08 | — | — | EP | disclosed |
| US-5726182-A | TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1998-03-10 | — | — | US | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |
| US-5580872-A | ADMINISTERING IN THE TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1996-12-03 | — | — | US | disclosed |
| WO-1995010519-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1995-04-20 | — | — | WO | disclosed |