Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504696 | 0.89 | MAPKAPK2 (0.49) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7505086 | 0.88 | SIGMAR1 (0.57) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7507230 | 0.83 | TP53 (0.52) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7503170 | 0.82 | MAPKAPK2 (0.54) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8041821 | 0.82 | MAPKAPK2 (0.50) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7506585 | 0.82 | MAPKAPK2 (0.53) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7504077 | 0.81 | MAPKAPK2 (0.49) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6237350 | 0.81 | MAPKAPK2 (0.55) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7510021 | 0.80 | TP53 (0.56) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7506122 | 0.80 | MAPKAPK2 (0.48) | SIGMAR1SLC6A4CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064284-B1 | HYPNOTIC BETA-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | MACEF (FR) | 2002-03-27 | — | — | EP | claimed |
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | claimed |
| EP-1091959-B1 | NOVEL PYRROLO-(3,4-B)QUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICAMENT | MACEF (FR) | 2002-10-23 | — | — | EP | disclosed |
| EP-1064284-B1 | HYPNOTIC BETA-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | MACEF (FR) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000069875-A9 | C-2 MODIFIED ERYTHROMYCIN DERIVATIVES | ABBOTT LAB (US) | 2002-02-21 | — | — | WO | disclosed |
| US-6335346-B1 | HYPNOTIC AGENTS, SEDATIVES | MACEF (FR) | 2002-01-01 | — | — | US | disclosed |
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |
| EP-0929563-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | disclosed |