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Carbamic Acid

Carbamic Acid

SCHEMBL7502884

CCCCNc1nc(Sc2ccc(C(F)(F)F)cc2)nc2c1nnn2[C@@H]1CC[C@@H](O)[C@H]1O.NC(=O)O

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ P2RY12 Q9H244 15/20 0.53
▸ FLT3 P36888 2/20 0.36
▸ TYRO3 Q06418 2/20 0.36
▸ MERTK Q12866 2/20 0.36
▸ GAS6 Q14393 2/20 0.36
▸ AXL P30530 1/20 0.36
▸ NAE1 Q13564 1/20 0.35
▸ UBA3 Q8TBC4 1/20 0.35
▸ TLR8 Q9NR97 1/20 0.34
▸ TLR7 Q9NYK1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL7514070 0.98 P2RY12 (0.52) P2RY12FLT3TYRO3MERTKGAS6
SCHEMBL7510476 0.93 P2RY12 (0.48) P2RY12FLT3TYRO3MERTKGAS6
Carbamic Acid SCHEMBL7518952 0.91 P2RY12 (0.57) P2RY12NAE1UBA3
Bicarbonate SCHEMBL7510964 0.88 P2RY12 (0.56) P2RY12NAE1UBA3
SCHEMBL7509882 0.86 P2RY12 (0.70) P2RY12
SCHEMBL7507169 0.86 P2RY12 (0.72) P2RY12
SCHEMBL7507158 0.86 P2RY12 (0.72) P2RY12
SCHEMBL7509278 0.86 P2RY12 (0.53) P2RY12FLT3TYRO3MERTKGAS6
SCHEMBL7509281 0.86 P2RY12 (0.53) P2RY12FLT3TYRO3MERTKGAS6
SCHEMBL7509891 0.86 P2RY12 (0.70) P2RY12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946561-B1 TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS ASTRAZENECA AB (SE) 2002-02-13 — — EP claimed
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