Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 15/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.36 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL7502884 | 0.98 | P2RY12 (0.53) | P2RY12FLT3TYRO3MERTKGAS6 | |
| SCHEMBL7510476 | 0.94 | P2RY12 (0.48) | P2RY12FLT3TYRO3MERTKGAS6 | |
| Bicarbonate SCHEMBL7510964 | 0.90 | P2RY12 (0.56) | P2RY12NAE1UBA3 | |
| Carbamic Acid SCHEMBL7518952 | 0.88 | P2RY12 (0.57) | P2RY12NAE1UBA3 | |
| SCHEMBL7509882 | 0.87 | P2RY12 (0.70) | P2RY12 | |
| SCHEMBL7509281 | 0.87 | P2RY12 (0.53) | P2RY12FLT3TYRO3MERTKGAS6 | |
| SCHEMBL7509278 | 0.87 | P2RY12 (0.53) | P2RY12FLT3TYRO3MERTKGAS6 | |
| SCHEMBL7509891 | 0.87 | P2RY12 (0.70) | P2RY12 | |
| Bicarbonate SCHEMBL7510727 | 0.86 | P2RY12 (0.52) | P2RY12NAE1UBA3 | |
| SCHEMBL7507158 | 0.85 | P2RY12 (0.72) | P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946561-B1 | TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |