Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6295365 | 0.87 | HSD11B1 (0.36) | HSD11B1ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL8298668 | 0.82 | PRKDC (0.37) | EGLN2 | |
| SCHEMBL9080441 | 0.81 | KDM4E (0.41) | MEN1CYP3A4CYP2C9CYP2C19HTT | |
| SCHEMBL7504113 | 0.81 | SCN9A (0.34) | SCN9A | |
| SCHEMBL7506245 | 0.80 | KDM4E (0.36) | CYP2C9CYP2C19KMT2ASMN1; SMN2 | |
| SCHEMBL7889504 | 0.80 | SLC34A1 (0.34) | SCN9AHTTFPR2PROKR1SLC34A1 | |
| SCHEMBL1554186 | 0.79 | ESR1 (0.35) | — | |
| SCHEMBL7514581 | 0.78 | HSD11B1 (0.36) | HSD11B1ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL7746904 | 0.77 | SLC34A1 (0.43) | HSD11B1MAPK14F2RL3SCN9ACYP3A4 | |
| SCHEMBL1555257 | 0.77 | KCNH2 (0.37) | PDE2ASIGMAR1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482774-B1 | Substituted (4-brompyrazole-3-yl) benzazoles | BASF AKTIENGESELLSCHAFT (DE) | 2002-11-19 | — | — | US | disclosed |
| EP-1076660-B1 | SUBSTITUTED (4-BROMPYRAZOLE-3-YL)BENZAZOLES | BASF AG (DE) | 2002-06-26 | — | — | EP | disclosed |
| CN-1302298-A | Substituted (4-brompyrazole-3-yl) indole | BASF AG (DE) | 2001-07-04 | — | — | CN | disclosed |