Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arformoterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 13/20 | 0.77 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.77 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | DRD2 | P14416 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | PGR | P06401 | 1/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | DRD3 | P35462 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arformoterol SCHEMBL6426856 | 1.00 | ADRB2 (0.77) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL5849657 | 0.94 | ADRB2 (0.87) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL328968 | 0.90 | ADRB2 (0.80) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL14890289 | 0.89 | ADRB2 (0.61) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL117865 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Formoterol SCHEMBL15856256 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL458736 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL3679114 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Arformoterol SCHEMBL4247 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 | |
| Formoterol SCHEMBL6528975 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708805-B9 | SEALS FOR USE IN AN AEROSOL DELIVERY DEVICE | MINNESOTA MINING & MFG (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-0708805-B2 | SEALS FOR USE IN AN AEROSOL DELIVERY DEVICE | MINNESOTA MINING & MFG (US) | 2010-12-22 | — | — | EP | disclosed |
| CN-100356913-C | Levo (R) bambuterol and its medicinal use | TAN W (CN) | 2007-12-26 | — | — | CN | disclosed |
| CN-1638756-A | Levo (R) bambuterol and its medicinal use | TAN W (ML) | 2005-07-13 | — | — | CN | disclosed |
| EP-0708805-B1 | SEALS FOR USE IN AN AEROSOL DELIVERY DEVICE | MINNESOTA MINING & MFG (US) | 1998-08-19 | — | — | EP | disclosed |