Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 14/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750757 | 0.90 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2135121 | 0.80 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL752840 | 0.76 | HCRTR1 (0.57) | HCRTR1HCRTR2 | |
| SCHEMBL27846930 | 0.72 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL751743 | 0.70 | HCRTR1 (0.56) | HCRTR1HCRTR2 | |
| SCHEMBL752475 | 0.69 | HCRTR1 (0.61) | HCRTR1HCRTR2 | |
| SCHEMBL750702 | 0.66 | HCRTR1 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL750766 | 0.64 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL750767 | 0.64 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL12093360 | 0.64 | HCRTR1 (0.43) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430004-A2 | NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-21 | — | — | EP | claimed |
| WO-2010131192-A2 | NOVEL OXAZOLIDINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | claimed |
| EP-2430004-A2 | NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131192-A2 | NOVEL OXAZOLIDINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |