Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516413 | 0.87 | POLB (0.37) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL6529359 | 0.81 | MAPT (0.48) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL20293767 | 0.80 | MAPT (0.47) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL28033810 | 0.80 | MAPT (0.47) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL7495006 | 0.75 | KCNN4 (0.42) | MAPTKMT2AKCNN4KIF11CHRM2 | |
| SCHEMBL4658941 | 0.74 | MAPT (0.47) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL5560839 | 0.74 | MAPT (0.47) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL3364484 | 0.74 | MAPT (0.52) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL9191857 | 0.74 | ESR1 (0.42) | MAPTKMT2AKIF11CHRM2CHRM1 | |
| SCHEMBL20556104 | 0.74 | MEN1 (0.38) | KMT2ACHRM2CHRM1CHRM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |