Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 8/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.45 |
| ▸ | PDE2A | O00408 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502701 | 0.86 | PDE1A (0.44) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL7507537 | 0.78 | PDE1A (0.51) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL2454975 | 0.77 | PDE1B (0.51) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL2461101 | 0.77 | PDE1A (0.50) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL12068584 | 0.74 | PDE1A (0.52) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL9608312 | 0.73 | USP1 (0.45) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL13334343 | 0.72 | PDE1B (0.42) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL17849334 | 0.69 | PDE1A (0.43) | PDE1APDE1BPDE1CPDE2AUSP1 | |
| SCHEMBL2453873 | 0.69 | PDE1A (0.48) | PDE1APDE1BPDE1CPDE2ATP53 | |
| SCHEMBL7505214 | 0.68 | PDE1A (0.48) | PDE1APDE1BPDE1CPDE2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371327-B2 | PDE1 inhibitor compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371327-B2 | PDE1 inhibitor compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| EP-2590657-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2011153135-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011153135-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2011-12-08 | — | — | WO | disclosed |