SCHEMBL7510198

SCHEMBL7510198

CS(=O)(=O)c1ccc(-c2oc(COc3ccccc3)nc2-c2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 8/20 0.62
PPARD Q03181 3/20 0.50
NR4A2 P43354 7/20 0.48
PTGS1 P23219 3/20 0.48
NR4A1 P22736 3/20 0.47
NR4A3 Q92570 3/20 0.47
RXRA P19793 5/20 0.46
RXRB P28702 4/20 0.46
KDM4E B2RXH2 1/20 0.45
ABCC4 O15439 1/20 0.45
C5 P01031 1/20 0.45
LMNA P02545 1/20 0.45
CHRM2 P08172 1/20 0.45
CYP3A4 P08684 1/20 0.45
CHRM1 P11229 1/20 0.45
DRD2 P14416 1/20 0.45
HPGD P15428 1/20 0.45
TSHR P16473 1/20 0.45
TBXA2R P21731 1/20 0.45
HTR2A P28223 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7506240 1.00 PTGS2 (0.62) PTGS2PPARDNR4A2PTGS1NR4A1
SCHEMBL7505683 0.93 PTGS2 (0.59) PTGS2PPARDPTGS1
SCHEMBL7498789 0.92 PTGS2 (0.56) PTGS2PPARDNR4A2PTGS1NR4A1
SCHEMBL7502050 0.92 PTGS2 (0.56) PTGS2PPARDNR4A2PTGS1NR4A1
SCHEMBL7505609 0.92 PTGS2 (0.58) PTGS2PPARDNR4A2PTGS1
SCHEMBL7497858 0.92 PTGS2 (0.58) PTGS2PPARDNR4A2PTGS1
SCHEMBL7508729 0.90 PTGS2 (0.54) PTGS2PPARDNR4A2PTGS1NR4A1
SCHEMBL7497356 0.90 PTGS2 (0.54) PTGS2PPARDNR4A2PTGS1NR4A1
SCHEMBL7506167 0.90 PTGS2 (0.53) PTGS2PPARDNR4A2PTGS1RXRA
SCHEMBL7502448 0.90 PTGS2 (0.53) PTGS2PPARDNR4A2PTGS1RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699192-B1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2002-07-24 EP claimed
EP-0699192-A1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-03-06 EP claimed
WO-1994027980-A1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1994-12-08 WO claimed
EP-0699192-B1 SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2002-07-24 EP disclosed
US-6090834-A ANALGESICS; RHEUMATIC DISORDERS; SKIN DISORDERS; GASTROINTESTINAL DISORDERS G.D. SEARLE & CO. (US) 2000-07-18 US disclosed
EP-0825989-A1 SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1998-03-04 EP disclosed
US-5719163-A ARTHRITIS G.D. SEARLE & CO. (US) 1998-02-17 US disclosed
WO-1996036617-A1 SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-11-21 WO disclosed