Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445833 | 0.93 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL443930 | 0.91 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL443358 | 0.89 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL445827 | 0.89 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| Lidorestat SCHEMBL419032 | 0.87 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| Lidorestat SCHEMBL29387869 | 0.87 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL445068 | 0.87 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| SCHEMBL2099099 | 0.87 | AKR1A1 (1.00) | AKR1A1AKR1B1 | |
| Lidorestat SCHEMBL6103908 | 0.87 | AKR1A1 (0.98) | AKR1A1AKR1B1 | |
| SCHEMBL444091 | 0.86 | AKR1A1 (1.00) | AKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6426344-B2 | INDOLEALKANOIC ACID DERIVATIVES INHIBITS ALDOSE REDUCTASE AND USEFUL FOR TREATING CHRONIC COMPLICATION ASSOCIATED WITH DIABETES MELLITUS INCLUDING DIABETIC CATARACTS, RETINOPATHY, NEPHROPATHY AND NEUROPATHY | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2002-07-30 | — | — | US | claimed |