Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518257 | 0.87 | POLB (0.43) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7514703 | 0.84 | ALDH1A1 (0.44) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7511753 | 0.83 | PIK3CD (0.44) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7511488 | 0.83 | PIK3CD (0.43) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7510642 | 0.83 | POLB (0.46) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7520791 | 0.81 | PIK3CD (0.42) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8805022 | 0.81 | PDE7A (0.43) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7513112 | 0.81 | PIK3CD (0.42) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8810900 | 0.79 | PIK3CD (0.42) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6222959 | 0.77 | ALDH1A1 (0.63) | PIK3CDPOLBALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |