Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28010037 | 0.83 | HDAC6 (0.49) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL27821681 | 0.83 | HDAC6 (0.49) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL27882319 | 0.81 | HDAC6 (0.47) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL27845616 | 0.80 | HDAC6 (0.46) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL26461278 | 0.80 | TSHR (0.52) | ALDH1A1HSD17B10APAF1KMT2ALMNA | |
| SCHEMBL18922945 | 0.77 | HDAC6 (0.44) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 | |
| SCHEMBL28493114 | 0.76 | KMT2A (0.47) | HDAC3HDAC4HDAC1ALDH1A1HSD17B10 | |
| SCHEMBL28493115 | 0.76 | KMT2A (0.47) | HDAC3HDAC4HDAC1ALDH1A1HSD17B10 | |
| SCHEMBL9209754 | 0.76 | MEN1 (0.47) | HSD17B10APAF1KMT2AMEN1PKM | |
| SCHEMBL28712237 | 0.76 | KMT2A (0.43) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951284-A4 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMA (IL) | 2002-03-20 | — | — | EP | disclosed |
| EP-0951284-A1 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998026775-A1 | PHENYLETHYLAMINE DERIVATIVES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1998-06-25 | — | — | WO | disclosed |