Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 4/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512235 | 0.89 | TBXA2R (0.54) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| SCHEMBL7514000 | 0.84 | ALDH1A1 (0.51) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7513995 | 0.83 | ALDH1A1 (0.50) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7298999 | 0.82 | TBXA2R (0.47) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7511013 | 0.81 | TBXA2R (0.54) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7511040 | 0.81 | TBXA2R (0.53) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| SCHEMBL27510090 | 0.80 | ALDH1A1 (0.47) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| Hydrochloric Acid SCHEMBL7515917 | 0.79 | TBXA2R (0.47) | TBXA2RALDH1A1KDM1ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL7510737 | 0.79 | TBXA2R (0.51) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A | |
| SCHEMBL7510788 | 0.79 | TBXA2R (0.51) | TBXA2RALDH1A1L3MBTL1PNMTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |
| CN-1207098-A | Amidine and isothiourea derivatives as nitric oxide synthase inhibitors | ASTRA AB (SE) | 1999-02-03 | — | — | CN | disclosed |
| EP-0861250-A1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Astra Aktiebolag (SE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997017344-A1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRA AKTIEBOLAG (SE) | 1997-05-15 | — | — | WO | disclosed |