Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.52 |
| ▸ | MMP3 | P08254 | 6/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.52 |
| ▸ | MMP8 | P22894 | 5/20 | 0.52 |
| ▸ | MMP1 | P03956 | 5/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074155 | 0.84 | MMP2 (0.62) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7073281 | 0.82 | MMP2 (0.58) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7079193 | 0.78 | PPARG (0.56) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7079165 | 0.77 | MMP2 (0.54) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7075141 | 0.74 | MMP2 (0.80) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL27517321 | 0.72 | MMP2 (0.81) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7079276 | 0.72 | MMP2 (0.52) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7221011 | 0.70 | MMP2 (0.59) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7075406 | 0.70 | MMP2 (0.77) | MMP2MMP3MMP9MMP8MMP1 | |
| SCHEMBL7078224 | 0.70 | MMP2 (0.77) | MMP2MMP3MMP9MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968182-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998005635-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 1998-02-12 | — | — | WO | disclosed |