Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515681 | 0.89 | RXFP1 (0.53) | RXFP1TLR8TLR7DHFR | |
| SCHEMBL7515684 | 0.89 | RXFP1 (0.53) | RXFP1TLR8TLR7DHFR | |
| SCHEMBL7523775 | 0.84 | RXFP1 (0.55) | RXFP1DHFREGFRTYMS | |
| SCHEMBL7521450 | 0.80 | RXFP1 (0.56) | RXFP1DHFRCYP2D6EGFRTYMS | |
| SCHEMBL7512211 | 0.78 | RXFP1 (0.51) | RXFP1DHFRCYP2D6EGFRTYMS | |
| SCHEMBL7515653 | 0.78 | RXFP1 (0.62) | RXFP1DHFRCYP2D6EGFRTYMS | |
| SCHEMBL5203531 | 0.77 | CYP2D6 (0.39) | TLR8TLR7KCNH2CYP2D6 | |
| SCHEMBL7512187 | 0.77 | RXFP1 (0.52) | RXFP1DHFRCYP2D6EGFRTYMS | |
| SCHEMBL7516524 | 0.76 | RXFP1 (0.54) | RXFP1DHFRCYP2D6EGFRTYMS | |
| SCHEMBL7510622 | 0.76 | RXFP1 (0.54) | RXFP1DHFRCYP2D6EGFRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |