Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515681 | 1.00 | RXFP1 (0.53) | RXFP1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL7512201 | 0.89 | RXFP1 (0.50) | RXFP1TLR8TLR7DHFR | |
| SCHEMBL7523775 | 0.86 | RXFP1 (0.55) | RXFP1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7512211 | 0.78 | RXFP1 (0.51) | RXFP1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7515653 | 0.78 | RXFP1 (0.62) | RXFP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7521450 | 0.77 | RXFP1 (0.56) | RXFP1KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL7512196 | 0.77 | RXFP1 (0.55) | RXFP1KDM4EALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL5209419 | 0.76 | KDM4E (0.43) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL7516524 | 0.76 | RXFP1 (0.54) | RXFP1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7510622 | 0.76 | RXFP1 (0.54) | RXFP1KDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |