Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678657 | 1.00 | KDM4E (0.55) | KDM4EFAAHMCHR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7517966 | 0.86 | MCHR1 (0.68) | KDM4EMCHR1 | |
| Hydrochloric Acid SCHEMBL6680315 | 0.86 | MCHR1 (0.68) | KDM4EMCHR1 | |
| Hydrochloric Acid SCHEMBL6658225 | 0.85 | MEN1 (0.53) | KDM4EMCHR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6662216 | 0.85 | MEN1 (0.53) | KDM4EMCHR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6662222 | 0.85 | MEN1 (0.53) | KDM4EMCHR1MEN1KMT2A | |
| SCHEMBL6908168 | 0.84 | L3MBTL1 (0.50) | — | |
| SCHEMBL6659429 | 0.84 | L3MBTL1 (0.50) | — | |
| SCHEMBL1190538 | 0.84 | MCHR1 (0.63) | KDM4EMCHR1MEN1KMT2ATSHR | |
| SCHEMBL7473424 | 0.84 | MCHR1 (0.63) | KDM4EMCHR1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257544-A2 | PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE | Vertex Pharmaceuticals Incorporated (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001058891-A2 | PIPERAZINE AND PIPERIDINE DERIVATIVES FOR TREATMENT OR PREVENTION OF NEURONAL DAMAGE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-08-16 | — | — | WO | disclosed |