Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512391 | 1.00 | KMT2A (0.57) | KMT2AMEN1POLBTP53LMNA | |
| SCHEMBL6222276 | 0.88 | LMNA (0.54) | KMT2ATP53LMNAMAPT | |
| SCHEMBL6222277 | 0.88 | LMNA (0.54) | KMT2ATP53LMNAMAPT | |
| SCHEMBL7514707 | 0.87 | TP53 (0.58) | KMT2AMEN1POLBTP53ALDH1A1 | |
| SCHEMBL7514701 | 0.87 | TP53 (0.58) | KMT2AMEN1POLBTP53ALDH1A1 | |
| SCHEMBL7509789 | 0.85 | TP53 (0.51) | KMT2AMEN1TP53LMNAMAPT | |
| SCHEMBL7511743 | 0.85 | TP53 (0.51) | KMT2AMEN1POLBTP53LMNA | |
| SCHEMBL7509786 | 0.85 | TP53 (0.51) | KMT2AMEN1TP53LMNAMAPT | |
| SCHEMBL7517191 | 0.85 | TP53 (0.51) | KMT2AMEN1POLBTP53LMNA | |
| SCHEMBL7510646 | 0.83 | TP53 (0.55) | KMT2AMEN1POLBTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | claimed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | claimed |
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |