Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 14/20 | 0.51 |
| ▸ | CAPNS1 | P04632 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27430964 | 1.00 | CAPN1 (0.51) | CAPN1CAPNS1ALDH1A1SMN1; SMN2REN | |
| SCHEMBL27428206 | 0.93 | CAPN1 (0.57) | CAPN1CAPNS1ALDH1A1 | |
| SCHEMBL7515309 | 0.93 | CAPN1 (0.57) | CAPN1CAPNS1ALDH1A1 | |
| SCHEMBL27428208 | 0.93 | CAPN1 (0.57) | CAPN1CAPNS1ALDH1A1 | |
| SCHEMBL7515987 | 0.80 | CTSK (0.61) | CTSLCTSBCTSSCTSK | |
| SCHEMBL8810895 | 0.80 | CAPN1 (0.55) | CAPN1CAPNS1CTSK | |
| SCHEMBL8808483 | 0.80 | CAPN1 (0.51) | CAPN1CAPNS1SMN1; SMN2CTSLCTSS | |
| SCHEMBL8808493 | 0.80 | CAPN1 (0.51) | CAPN1CAPNS1SMN1; SMN2CTSLCTSS | |
| SCHEMBL8812311 | 0.78 | CAPN1 (0.51) | CAPN1CAPNS1ALDH1A1CTSLCTSB | |
| SCHEMBL8812325 | 0.78 | CAPN1 (0.51) | CAPN1CAPNS1ALDH1A1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| CN-1106001-A | Lactol derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-02 | — | — | CN | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |