Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965502 | 0.95 | HRH3 (0.37) | GRIN1GRIN2BHRH3SLC6A4MEN1 | |
| SCHEMBL7556966 | 0.89 | HRH3 (0.36) | GRIN1GRIN2BHRH3SLC6A4MEN1 | |
| SCHEMBL5965706 | 0.81 | HRH3 (0.40) | GRIN1GRIN2BHRH3SLC6A4MEN1 | |
| SCHEMBL7093343 | 0.80 | HRH3 (0.41) | GRIN1GRIN2BHRH3SLC6A4MEN1 | |
| SCHEMBL3143065 | 0.77 | HRH3 (0.52) | HRH3MEN1KMT2A | |
| SCHEMBL6987525 | 0.76 | HRH3 (0.37) | GRIN1GRIN2BHRH3SLC6A4MEN1 | |
| SCHEMBL5965411 | 0.73 | HRH3 (0.40) | HRH3SLC6A4MEN1KMT2A | |
| SCHEMBL21400657 | 0.73 | APP (0.44) | PTPN1HRH3MEN1KMT2A | |
| SCHEMBL15093959 | 0.73 | MEN1 (0.43) | PTPN1MEN1KMT2ACA12CA2 | |
| SCHEMBL15093765 | 0.73 | MEN1 (0.43) | PTPN1MEN1KMT2ACA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192155-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076997-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |