Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965706 | 0.88 | HRH3 (0.40) | HRH3SLC6A4TRPC6GRIN1GRIN2B | |
| SCHEMBL5965502 | 0.84 | HRH3 (0.37) | HRH3SLC6A4TRPC6GRIN1GRIN2B | |
| SCHEMBL5965411 | 0.84 | HRH3 (0.40) | HRH3SLC6A4MEN1KMT2A | |
| SCHEMBL6987525 | 0.83 | HRH3 (0.37) | HRH3SLC6A4TRPC6GRIN1GRIN2B | |
| SCHEMBL3143065 | 0.81 | HRH3 (0.52) | HRH3TRPC6MEN1KMT2A | |
| SCHEMBL7556966 | 0.81 | HRH3 (0.36) | HRH3SLC6A4GRIN1GRIN2BMEN1 | |
| SCHEMBL7513396 | 0.80 | GRIN1 (0.38) | HRH3SLC6A4GRIN1GRIN2BMEN1 | |
| SCHEMBL5965958 | 0.78 | HRH3 (0.37) | HRH3SLC6A4MEN1KMT2AKCNH2 | |
| SCHEMBL7250411 | 0.77 | SLC6A4 (0.43) | HRH3SLC6A4GRIN1GRIN2BMEN1 | |
| SCHEMBL5965701 | 0.77 | GPR119 (0.42) | HRH3SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1328526-A1 | 3,8-DIAZABICYCLO[3.2.1]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002032902-A1 | 3,8-DIAZABICYCLO[3.2.1]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-04-25 | — | — | WO | disclosed |