SCHEMBL7513546

SCHEMBL7513546

COc1ccc2c(c1)C(=O)C(C=O)CC2

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.55
CYP19A1 P11511 4/20 0.54
METAP1 P53582 2/20 0.47
MAOB P27338 2/20 0.46
DRD2 P14416 1/20 0.44
DRD3 P35462 1/20 0.44
CYP24A1 Q07973 2/20 0.42
CYP26A1 O43174 1/20 0.42
CYP27A1 Q02318 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MAOA P21397 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7519184 0.88 CYP24A1 (0.54) CYP19A1METAP1DRD2CYP24A1CYP26A1
SCHEMBL5237012 0.81 ACHE (0.71) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL5237018 0.81 ACHE (0.71) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL5237022 0.81 ACHE (0.71) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL8599809 0.80 CYP19A1 (0.62) ACHECYP19A1METAP1CYP24A1CYP26A1
SCHEMBL3875408 0.80 ACHE (0.56) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL992002 0.80 ACHE (0.56) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL13363970 0.80 ACHE (0.56) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL6630846 0.80 ACHE (0.56) ACHECYP19A1METAP1MAOBDRD2
SCHEMBL31040171 0.80 CYP19A1 (0.59) ACHECYP19A1METAP1MAOBDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0856001-B1 PYRIMIDINE DERIVATIVES AS 5HT2C RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2002-08-28 EP disclosed
US-5753663-A 5HT2C ANTAGONIST, USEFUL FOR TREATING ANXIETY, PAIN, OBSESSIVE COMPULSIVE DISORDER, ALCOHOLISM, DEPRESSION, MIGRAINE, SLEEP DISORDER, ANOREXIA NERVOSA AND PRIAPISM SYNTEX (U.S.A.) INC. (US) 1998-05-19 US disclosed