Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133234 | 0.86 | HDAC4 (0.52) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8133237 | 0.86 | HDAC4 (0.52) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL6582894 | 0.85 | CTSK (0.48) | CTSKCTSSCTSLCTSBHDAC4 | |
| SCHEMBL8121033 | 0.84 | KMT2A (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8387090 | 0.84 | KMT2A (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL8121031 | 0.84 | KMT2A (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL4320742 | 0.83 | CTSK (0.46) | CTSKCTSSCTSLCTSBHDAC4 | |
| SCHEMBL4320739 | 0.83 | CTSK (0.46) | CTSKCTSSCTSLCTSBHDAC4 | |
| SCHEMBL4310648 | 0.82 | CTSK (0.47) | CTSKCTSSCTSLCTSBHDAC4 | |
| SCHEMBL5099466 | 0.82 | CTSK (0.47) | CTSKCTSSCTSLCTSBHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991753-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0991753-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998050534-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |