Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502243 | 0.94 | MAPK13 (0.38) | CHRM4DRD2HTR7CHEK1EED | |
| SCHEMBL7508487 | 0.94 | MAPK13 (0.38) | CHRM4DRD2HTR7CHEK1EED | |
| SCHEMBL7509290 | 0.91 | MAP2 (0.39) | CHEK1HTR6MAPTCHRNB2CHRNA4 | |
| SCHEMBL7506691 | 0.90 | CHRM4 (0.43) | CHRM4DRD2HTR7CHEK1EED | |
| SCHEMBL7504471 | 0.89 | CHRNB2 (0.35) | CHRM4DRD2HTR7CHEK1LMNA | |
| SCHEMBL7511840 | 0.89 | MAPK10 (0.40) | CHEK1HTR6 | |
| SCHEMBL7506495 | 0.89 | CHEK1 (0.41) | CHRM4DRD2HTR7CHEK1EED | |
| SCHEMBL7508685 | 0.88 | CYP11B1 (0.40) | CHRM4DRD2HTR7 | |
| SCHEMBL7511739 | 0.86 | CHEK1 (0.36) | CHRM4DRD2HTR7CHEK1EED | |
| SCHEMBL7507840 | 0.85 | KCNH2 (0.35) | CHEK1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |