Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524053 | 0.90 | RXFP1 (0.47) | RXFP1NPY5RHTR1ADRD2DRD4 | |
| SCHEMBL7521012 | 0.90 | RXFP1 (0.47) | RXFP1HTR1ADRD2DRD4MAPK3 | |
| SCHEMBL7514853 | 0.89 | RXFP1 (0.46) | RXFP1NPY5RHTR1ADRD2DRD4 | |
| SCHEMBL7514857 | 0.89 | RXFP1 (0.46) | RXFP1NPY5RHTR1ADRD2DRD4 | |
| SCHEMBL7520253 | 0.87 | RXFP1 (0.44) | RXFP1HTR1ADRD2DRD4MAPK3 | |
| SCHEMBL7510904 | 0.83 | RXFP1 (0.51) | RXFP1HTR1ADRD2DRD4SYK | |
| SCHEMBL7510908 | 0.83 | RXFP1 (0.51) | RXFP1HTR1ADRD2DRD4SYK | |
| SCHEMBL7515467 | 0.81 | RXFP1 (0.48) | RXFP1HTR1ADRD2DRD4SYK | |
| SCHEMBL7515471 | 0.81 | RXFP1 (0.48) | RXFP1HTR1ADRD2DRD4SYK | |
| SCHEMBL7513904 | 0.79 | RXFP1 (0.49) | RXFP1HTR1ADRD2DRD4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |