Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513830 | 0.87 | RXFP1 (0.49) | RXFP1SYKMAPK8MAPK9HTR1A | |
| SCHEMBL7521012 | 0.85 | RXFP1 (0.47) | RXFP1SYKHTR1ADRD2DRD4 | |
| SCHEMBL7524053 | 0.85 | RXFP1 (0.47) | RXFP1SYKMAPK8HTR1ADRD2 | |
| SCHEMBL7514857 | 0.84 | RXFP1 (0.46) | RXFP1SYKHTR1ADRD2DRD4 | |
| SCHEMBL7514853 | 0.84 | RXFP1 (0.46) | RXFP1SYKHTR1ADRD2DRD4 | |
| SCHEMBL7510904 | 0.79 | RXFP1 (0.51) | RXFP1SYKMAPK8MAPK9HTR1A | |
| SCHEMBL7510908 | 0.79 | RXFP1 (0.51) | RXFP1SYKMAPK8MAPK9HTR1A | |
| SCHEMBL7515467 | 0.76 | RXFP1 (0.48) | RXFP1SYKHTR1ADRD2DRD4 | |
| SCHEMBL7515471 | 0.76 | RXFP1 (0.48) | RXFP1SYKHTR1ADRD2DRD4 | |
| SCHEMBL7513913 | 0.75 | RXFP1 (0.49) | RXFP1SYKMAPK8MAPK9HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |