Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758345 | 1.00 | HTR1A (0.40) | HTR1APLGPLATSLC6A4 | |
| SCHEMBL5758581 | 1.00 | HTR1A (0.40) | HTR1APLGPLATSLC6A4 | |
| SCHEMBL5758577 | 1.00 | HTR1A (0.40) | HTR1APLGPLATSLC6A4 | |
| SCHEMBL5757274 | 0.84 | HTR1A (0.40) | HTR1ASLC6A4 | |
| SCHEMBL5756274 | 0.82 | HTR1A (0.43) | HTR1APLGSLC6A4 | |
| SCHEMBL5758273 | 0.82 | HTR1A (0.43) | HTR1APLGSLC6A4 | |
| SCHEMBL5756271 | 0.82 | HTR1A (0.43) | HTR1APLGSLC6A4 | |
| SCHEMBL5760384 | 0.78 | HTR1A (0.37) | HTR1APLGPLATSLC6A4 | |
| SCHEMBL7127432 | 0.78 | HTR1A (0.37) | HTR1APLGPLATSLC6A4 | |
| SCHEMBL5760244 | 0.78 | HTR1A (0.37) | HTR1APLGPLATSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242411-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | ELI LILLY AND COMPANY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046181-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AND ANXIETY | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |